Pretty sure the nodule gears are not good to use against the Mother Slime, since it raises ML and therefore how hard she hits and how high her hp goes, but I don't know for a fact. What I do know is that she's the only thing left in there and kicking my tail to Hey Deze with all her slimiy powers. I think her HP should be around 2k-3k with all the turns it took me to get to her, according to her hp formula on the wiki. That being said, I only have moderate or slight slime resistance and I have trouble hitting her. I'm going to try buffing up as much as possible and attempting it 2-5 more times, and then I think I'm going to ascend, assuming I can still get some loots from this after I do.
Edit: Wow, I drank a ton of muscle-boosting potions to take advantage of my shield skill as a TT and to boost my damage, and found out the hard way Mother Slime has that damage adaptation that makes her mostly immune to a specific type of damage after taking 500 or more damage from it. Well, I can only do 1 or 2 types of damage, so unless you guys think I might be able to Nuclear Breath her and then Turtle of the Seven Tails for the win, I don't see any possible way *to* win.
Edit again: Yep, the Nuclear Breath + Spleen abuse + Turtle of the Seven Tails + tons of muscly saucepots and other goodies resulted in victory. Hooray, my first Mother Slime down.
Edit x3: We got, as loot, a Slime-Soaked Brain, and a Hardened Slime belt. Both of them seem pretty neat, but I have no idea what they are mainly good for. I don't have a preference, and I'm wondering if the skill one (the brain) can be somehow sold to other players? I seem to remember reading that somewhere.